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October 2, 2025

Newly diagnosed T-large granular lymphocyte Leukemia presenting with severe neutropenia: a case report.

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Case report reveals treatment efficacy for severe neutropenia in T-LGLL using oral cyclophosphamide.

The patient achieved normalization of neutrophil levels after oral cyclophosphamide treatment, indicating effective management.
Flow cytometry confirmed the diagnosis of T-LGLL with a distinct CD3+, CD8+, CD57+ phenotype, crucial for tailored therapy.
Initial treatment with low-dose methotrexate was ineffective, highlighting the need for personalized immunosuppressive strategies.
This case underscores the importance of early diagnosis and appropriate intervention in managing T-LGLL with neutropenia.

Asmar et al. (2025) studied this question.

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