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This study examines the prevalence and characteristics of co-occurrence between LGLL and plasma cell dyscrasias.

August 7, 2026LeukemiaOpen Access

Multilineage lymphoid clonal hematopoiesis: a cross-sectional, correlative analysis of plasma cell dyscrasias and large granular lymphocytic leukemia

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Cross-sectional analysis finds significant co-occurrence of LGLL and plasma cell dyscrasias, indicating important clinical implications.

This study examines the prevalence and characteristics of co-occurrence between LGLL and plasma cell dyscrasias.
Conducted a cross-sectional analysis involving 2064 plasma cell dyscrasias cases and 534 LGLL cases.
Analyzed clinical features and co-occurrence rates between LGLL and plasma cell dyscrasias.
Investigated associations with autoimmune conditions and biological parameters.
20% of LGLL cases co-occurred with plasma cell dyscrasias, while LGLL was found in 2% of plasma cell dyscrasias cases.
PCDs were strongly associated with IgM M-protein, and LGLL patients showed increased NK-cell proliferation.
Symptomatic PCD/LGLL patients with low plasma-cell infiltration benefited more from B-cell-targeted therapies than from immunosuppression.

Bravo‐Pérez et al. (2026) studied this question.

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