Key result
New-onset type 1 diabetes is linked to elevated lipid peroxidation and platelet activation, resolving after 1 year.
Why the study?
Early events related to the development of diabetic angiopathy in type 1 diabetes mellitus, including oxidant stress and platelet activation, were not well characterized.
Cross-Sectional
Enhanced lipid peroxidation and platelet activation are early events in type 1 diabetes mellitus, likely related to an acute inflammatory response, which may contribute to the development of diabetic angiopathy.
May indicate early vascular risk in new-onset type 1 diabetes; leaves open whether targeting oxidative stress alters angiopathy outcomes.
BACKGROUND: To investigate early events possibly related to the development of diabetic angiopathy, we examined whether 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) formation, a marker of in vivo oxidant stress, is altered in different stages of type 1 diabetes (T1DM) and whether it correlates with the rate of thromboxane (TX) A2 biosynthesis, a marker of in vivo platelet activation. We also investigated the relationship between inflammatory markers and F2-isoprostane formation in this setting. METHODS AND RESULTS: A cross-sectional study was performed in 23 insulin-treated patients aged <18 years with new-onset T1DM (<or=6 weeks, group A), matched for age and gender with 23 patients with stable disease (>1 year, group B). Urinary 8-iso-PGF2alpha and 11-dehydro-TXB2 were measured in all patients and in age- and gender-matched controls. Circulating interleukin-6 (IL-6), tumor necrosis factor-alpha, and C-reactive protein were also determined as markers of the inflammatory response. Fifteen of the 23 children in group A were reexamined after 12 months. Compared with either controls or group B, diabetic children in group A showed significantly higher levels of 8-iso-PGF2alpha, 11-dehydro-TXB2, IL-6, tumor necrosis factor-alpha, and C-reactive protein. Statistically significant correlations between IL-6 and both 8-iso-PGF2alpha (r=0.63, P<0.001) and 11-dehydro-TXB2 (r=0.51, P<0.01) were observed. The 15 patients reexamined after 1 year showed a significant reduction in lipid peroxidation and platelet activation (P<0.02 and P<0.001, respectively), consistent with reduced levels of IL-6 and tumor necrosis factor-alpha. CONCLUSIONS: These results demonstrate that enhanced lipid peroxidation and platelet activation represent early events in T1DM that are possibly related to an acute inflammatory response. These noninvasive indexes may help in further examining T1DM pathophysiology and monitoring pharmacological interventions to interfere with disease development and progression.
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Davı̀ et al. (2003) conducted a cross-sectional in Type 1 Diabetes Mellitus. New-onset Type 1 Diabetes Mellitus vs. Stable Type 1 Diabetes Mellitus and healthy controls was evaluated on Urinary 8-iso-PGF2alpha and 11-dehydro-TXB2 levels. New-onset type 1 diabetes was associated with enhanced lipid peroxidation and platelet activation compared to stable disease or controls, which significantly decreased after 1 year (P<0.02 and P<0.001).
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