Why the study?
LVOT obstruction is a common complication with high mortality during TMVR, making prediction and prevention essential.
Do LAMPOON techniques prevent or manage left ventricular outflow tract obstruction in patients undergoing transcatheter mitral valve replacement?
Do LAMPOON techniques prevent or manage left ventricular outflow tract obstruction in patients undergoing transcatheter mitral valve replacement?
LAMPOON is a transcatheter electrosurgical technique that splits the anterior mitral valve leaflet to prevent or treat LVOT obstruction during TMVR.
May support LAMPOON consideration to mitigate LVOT obstruction in TMVR; leaves open randomized validation.
Transcatheter mitral valve replacement (TMVR) is a therapeutic option for patients with severe mitral disease who are deemed inoperable due to their overall surgical risk. The close relationships between the left ventricular outflow tract (LVOT) and the anterior mitral valve leaflet can lead to LVOT obstruction, a common complication with high mortality. Predicting and preventing LVOT obstruction is therefore essential, prior to TMVR. Laceration of the Anterior Mitral leaflet to Prevent Outflow ObtructioN (LAMPOON) is a transcatheter electrosurgical technique to split the anterior mitral valve leaflet immediately prior to TMVR. The technique has been studied in a prospective clinical trial and has evolved with many iterations for specific anatomies. In this review, we discuss the different LAMPOON techniques to prevent and treat LVOT obstruction.
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Case et al. (2021) studied this question.
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