This study establishes that the ventricle is the major production site of brain natriuretic peptide (BNP) in the human heart, providing foundational knowledge for its use as a cardiac biomarker.
Answers are grounded in this paper and cite their sources.
Animal data support ventricular BNP production; leaves open human translation for hypertension biomarkers.
To elucidate the expression of the brain natriuretic peptide gene in the human heart, we have measured brain natriuretic peptide mRNA levels in hearts using the Northern blot hybridization method. Brain natriuretic peptide mRNA was present with a size of approximately 0.9 kb in the ventricle as well as in the atrium. The brain natriuretic peptide mRNA level in the ventricle was 52% of that in the atrium, whereas the atrial natriuretic peptide mRNA level in the ventricle was approximately two orders of magnitude lower than that in the atrium. Taking atrial and ventricular weights into account, the total amount of brain natriuretic peptide mRNA in the ventricle represented 77% of that in the whole heart. These results demonstrate that most of brain natriuretic peptide mRNA occurs in the ventricle, in contrast with atrial natriuretic peptide mRNA, which is present mainly in the atrium, indicating that the ventricle is a major production site of brain natriuretic peptide.
No takes yet. Share an insight, caveat, or question.
Hosoda et al. (1991) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: