What question did this study set out to answer?

This research aims to investigate the role of the orbitofrontal cortex in the pathophysiology of major depression.

Orbitofrontal Cortex Function and Structure in Depression

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Randomized trial reveals OFC activity's role in mood regulation in individuals with major depression, suggesting new treatment implications.

This research aims to investigate the role of the orbitofrontal cortex in the pathophysiology of major depression.
Utilized neuroimaging, neuropathologic, and lesion analysis techniques to assess OFC function and structure.
Examined correlations between physiological activity in the OFC and severity of depression in affected individuals.
Analyzed grey-matter volumetric reductions and emotional responses among patients with mood disorders.
Posterior lateral and medial OFC activity inversely correlates with depression severity (specific metrics not provided).
Increased activity in the anteromedial OFC during depression phases positively correlates with severity (exact metrics not specified).
Effective antidepressant treatment reduces activity in the anteromedial OFC, indicating a potential therapeutic target.

Wayne C. Drevets (2007) studied this question.

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Randomized trial reveals OFC activity's role in mood regulation in individuals with major depression, suggesting new treatment implications.