In vertebrates, tight junctions (TJs) play a central role in sealing the intercellular space in epithelial and endothelial cellular sheets ([Schneeberger and Lynch 1992][1]; [Gumbiner 1993][2]; [Anderson and van Itallie 1995][3]). Without TJs, these cellular sheets cannot function as barriers to
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Tsukita et al. (2000) studied this question.
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