August 1, 2003Journal of Biological ChemistryOpen Access

Direct Activation of AMP-activated Protein Kinase Stimulates Nitric-oxide Synthesis in Human Aortic Endothelial Cells

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Population

Human aortic endothelial cells

Comparison

5'-aminoimidazole-4-carboxamide ribonucleoside vs Adenovirus-mediated expression of a dominant…

Design

Preclinical

Authors

VMValerie MorrowWestern Infirmary FFFabienne FoufelleInserm JCJohn ConnellPreventive Cardiology

Discussion

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Implication

Links AMPK to endothelial NO production; leaves open its contribution to vascular tone in vivo.

Structured PICO

Population

Human aortic endothelial cells

Intervention

5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

Comparator

Adenovirus-mediated expression of a dominant negative AMPK mutant

Outcome

Nitric-oxide (NO) production and eNOS Ser-1177 phosphorylationsurrogate

Direct activation of AMPK stimulates NO production in human aortic endothelial cells via eNOS phosphorylation, suggesting a mechanism for local vascular tone control.

Cite This Study

Morrow et al. (2003) studied this question.

synapsesocial.com/papers/6a014b3d7ac91c5d2a2d76d3 https://doi.org/10.1074/jbc.m212831200

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Direct Activation of AMP-activated Protein Kinase Stimulates Nitric-oxide Synthesis in Human Aortic Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Direct Activation of AMP-activated Protein Kinase Stimulates Nitric-oxide Synthesis in Human Aortic Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider