ions in PBS. Furthermore, the delivery of DOX from MBG nanospheres into cell culture environment shows a significant inhibitory effect on the viability of osteosarcoma cells with the increase of interaction time. The prepared MBG nanospheres have high specific surface area and mesopore volume, excellent apatite-mineralization ability, distinct degradability, high DOX-loading efficiency and controllable DOX release as well as anti-cancer functions. These unique characteristics suggest that the obtained MBG nanospheres may be used for the therapy of bone cancer.
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Wu et al. (2013) studied this question.
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