Answers are grounded in this paper and cite their sources.
Review reveals advances in intermolecular metal-catalyzed cycloaddition across three distinct alkynes, indicating improved selectivity in complex arene synthesis.
Synthetic sequel: The transition-metal-catalyzed [2+2+2] cycloaddition is an established method for the construction of carbocyclic frameworks but is often plagued by poor selectivity. Recent literature paints a promising picture--a more general metal-catalyzed [2+2+2] cycloaddition can be accomplished intermolecularly using three separate alkynes to furnish highly substituted arenas (see scheme).
No takes yet. Share an insight, caveat, or question.
Galan et al. (2009) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: