April 28, 2023European Journal of Heart Failure38 citationsOpen Access
View Full PaperIron Deficiency in Heart Failure: Screening, Prevalence, Incidence and Outcome Data from the Swedish Heart Failure Registry and the Stockholm CREAtinine Measurements Collaborative Project
Structured PICO
Is iron deficiency associated with worse clinical outcomes in patients with heart failure across the ejection fraction spectrum?
P
Population
15,197 patients with heart failure and available ejection fraction from the Swedish Heart Failure Registry (Region Stockholm), including a subgroup of 1,486 patients with iron biomarkers at baseline.
I
Intervention
Presence of iron deficiency (observational exposure)
C
Comparator
Absence of iron deficiency
O
Outcome
Heart failure rehospitalizations and composite of cardiovascular death or repeated heart failure hospitalizationshard clinical
Iron deficiency is highly prevalent in heart failure across all ejection fractions, remains under-screened, and is independently associated with an increased risk of heart failure rehospitalizations and cardiovascular death.
Abstract
AIMS: Iron deficiency (ID) is common in heart failure (HF) and linked with poor prognosis regardless of anaemia. We assessed temporal trends in ID testing, ID prevalence, ID incidence, iron need, and outcomes associated with ID in HF across the ejection fraction (EF) spectrum. METHODS AND RESULTS: From the Swedish HF registry, we enrolled 15 197 patients from Region Stockholm with available EF and collected laboratory tests from routine practice. Iron screening improved since 2016 but remained 1000 mg doses. These data highlight the need for improved screening for ID in HF.