Why the study?
While cardiac iron concentration is decreased in advanced HFrEF, it had never been measured in patients with non-advanced HFrEF.
Is cardiac iron concentration associated with systemic iron status and disease severity in patients with non-advanced non-ischaemic HFrEF?
Is cardiac iron concentration associated with systemic iron status and disease severity in patients with non-advanced non-ischaemic HFrEF?
In patients with non-advanced non-ischaemic HFrEF, low cardiac iron concentration correlates with disease severity but not with systemic iron levels, suggesting a localized myocardial iron deficiency.
May warrant cardiac-specific iron evaluation despite normal systemic markers in non-advanced non-ischaemic HFrEF; hypothesis-generating for localized deficiency.
AIMS: Low cardiac iron levels promote heart failure in experimental models. While cardiac iron concentration (CI) is decreased in patients with advanced heart failure with reduced ejection fraction (HFrEF), CI has never been measured in non-advanced HFrEF. We measured CI in left ventricular (LV) endomyocardial biopsies (EMB) from patients with non-advanced HFrEF and explored CI association with systemic iron status and disease severity. METHODS AND RESULTS: patients. CONCLUSION: Low CI is associated with greater disease severity in patients with non-advanced non-ischaemic HFrEF. CI is unrelated to systemic iron homeostasis. The prognostic and therapeutic implications of CI measurements in EMBs should be further explored.
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Hirsch et al. (2020) studied this question.
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