Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling

Junichiro Suzuki; Kiyoshi Yoshioka; Masahiro Kurita; 杉本匠; Takahiro Eguchi; Naoki Ito; Aoi Kodama; Yasutomi Kamei; Masahiro Ohtani; Toshiaki Matsutomo; Shin‐ichiro Imai

doi:10.1016/j.cmet.2026.04.006

May 1, 2026Cell MetabolismOpen Access

Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling

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Key Points

The aim is to investigate how a garlic-derived metabolite affects LKB1 activation and muscle function through adipose tissue signaling.
Examined the effects of the garlic-derived metabolite S1PC on the LKB1-SIRT1 pathway in white adipose tissue (WAT).
Conducted experiments on aged mice to observe the impact on muscle force and frailty indices.
Assessed circulating eNAMPT levels in human subjects with healthy adipose mass.
S1PC significantly activated the LKB1-SIRT1 pathway, resulting in increased eNAMPT secretion from WAT.
In aged mice, enhanced muscle force was observed alongside improved frailty indices.
Circulating levels of eNAMPT increased in human participants following S1PC administration.

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Implication

Shows garlic-derived metabolite enhances muscle function in aged individuals, indicating potential for aging interventions.

Abstract

-dependent protein deacetylase, SIRT1, and promoting the secretion of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in white adipose tissue (WAT). Interestingly, eNAMPT secreted from WAT specifically targets the hypothalamus, significantly enhancing skeletal muscle force and improving frailty indices in aged mice. Furthermore, S1PC is also able to increase circulating eNAMPT levels in human individuals who maintain healthy adipose mass. These findings demonstrate that S1PC specifically stimulates the LKB1-SIRT1 pathway and enhances eNAMPT secretion in WAT, counteracting skeletal muscle aging in aged individuals.

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Cite This Study

Suzuki et al. (2026) studied this question.

synapsesocial.com/papers/6a0171473a9f334c28271940 https://doi.org/10.1016/j.cmet.2026.04.006

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Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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