Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling

Key Points

• The aim is to investigate how a garlic-derived metabolite affects LKB1 activation and muscle function through adipose tissue signaling.
• Examined the effects of the garlic-derived metabolite S1PC on the LKB1-SIRT1 pathway in white adipose tissue (WAT).
• Conducted experiments on aged mice to observe the impact on muscle force and frailty indices.
• Assessed circulating eNAMPT levels in human subjects with healthy adipose mass.
• S1PC significantly activated the LKB1-SIRT1 pathway, resulting in increased eNAMPT secretion from WAT.
• In aged mice, enhanced muscle force was observed alongside improved frailty indices.
• Circulating levels of eNAMPT increased in human participants following S1PC administration.