What question did this study set out to answer?

This research aims to explore how exosome-delivered eNAMPT from exercise can counteract age-related liver disease.

May 13, 2026Aging Cell0 citationsOpen Access

Exosome‐Delivered eNAMPT From Exercise Activates SIRT1 to Counteract Age‐Related Hepatic Steatosis and Fibrosis

WSWenxuan SongNorth China University of Science and Technology NWNaijun WuNorth China University of Science and Technology Affiliated Hospital XLX LiNorth China University of Science and Technology

Key Points

This research aims to explore how exosome-delivered eNAMPT from exercise can counteract age-related liver disease.
Investigated the role of exercise in delivering eNAMPT through exosomes.
Analyzed the activation of SIRT1 in liver tissues.
Examined the impact of exosomal eNAMPT on hepatic steatosis and fibrosis.
Exercise activates SIRT1, contributing to reduced hepatic steatosis.
Demonstrated that eNAMPT from exosomes counters age-related fibrosis in the liver.
Identified exosomal eNAMPT as a potential therapeutic agent for liver diseases.

Abstract

-SIRT1 cascade. Collectively, our results elucidate a novel exosome-mediated pathway through which exercise mitigates age-related liver disease, positioning exosomal eNAMPT as a promising therapeutic agent and exercise mimetic for MASLD.

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