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Exercise improves hepatic steatosis and fibrosis in aging, suggesting exosomal eNAMPT as a promising therapeutic agent.
-SIRT1 cascade. Collectively, our results elucidate a novel exosome-mediated pathway through which exercise mitigates age-related liver disease, positioning exosomal eNAMPT as a promising therapeutic agent and exercise mimetic for MASLD.
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Song et al. (2026) studied this question.
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