P26 Cross-sectional associations between autism-related social difficulties, chronotype and sleep disruption in 89,602 UK biobank participants

the associations between autism-related social difficulties and chronotype or sleep disruption.Methods The UK Biobank is a population-based, longitudinal cohort study comprising over half a million middle-aged UK residents (n =502,128).A subset (n = 89,602) completed sleep and social situation questionnaires [UK Biobank project ID: 99491].Chronotype was calculated by rMEQ (Category 206) while sleep disruption was assessed by PSQI (Category 208).For social traits, latent class analysis was used to categorise the participants according to their answers to 16 questions on social situation (Category 1512).Logistic regression models were applied to investigate the relationship between autism-related social difficulties and chronotype or sleep disruption.