Whole-genome doubling drives immune evasion by silencing antigen presentation

Key Points

The research investigates how whole-genome doubling contributes to immune evasion by silencing antigen presentation.
Analyzed T cell infiltration in relation to whole-genome doubling.
Examined metabolic and epigenetic alterations linked to immune escape.
WGD leads to reduced antigen presentation, correlating with decreased T cell infiltration.
Metabolic and epigenetic changes are identified as key drivers of immune evasion.

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Demonstrates immune escape mechanisms driven by whole-genome doubling, highlighting critical metabolic and epigenetic changes.

T cell infiltration. Our results underscore metabolic and epigenetic alterations as critical drivers of WGD-associated immune escape.

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Foidart et al. (2026) studied this question.

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