Whole-genome doubling drives immune evasion by silencing antigen presentation

Key Points

• The research investigates how whole-genome doubling contributes to immune evasion by silencing antigen presentation.
• Analyzed T cell infiltration in relation to whole-genome doubling.
• Examined metabolic and epigenetic alterations linked to immune escape.
• WGD leads to reduced antigen presentation, correlating with decreased T cell infiltration.
• Metabolic and epigenetic changes are identified as key drivers of immune evasion.