What question did this study set out to answer?

To comprehensively examine the kinetic rates and thermodynamic equilibrium behaviors governing the formation and decomposition of Jackson-Meisenheimer sigma adducts.

April 1, 1982Chemical Reviews

Rate and equilibrium studies in Jackson-Meisenheimer complexes

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Authors

FTFrançois TerrierUniversity of Geneva

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Implication

Comprehensive review evaluates reaction rates and equilibrium states in Jackson-Meisenheimer complexes, highlighting thermodynamic principles that control nucleophilic aromatic substitution pathways.

Key Points

To comprehensively examine the kinetic rates and thermodynamic equilibrium behaviors governing the formation and decomposition of Jackson-Meisenheimer sigma adducts.
Literature-wide review and kinetic profiling of nucleophilic additions to electron-deficient aromatic systems.
Evaluation of experimental rate constants, equilibrium association constants, and activation parameters across varying solvent systems and substituent patterns.
Demonstrates that electron-withdrawing substituents on the aromatic ring significantly increase equilibrium stability and formation rates of anionic sigma adducts.
Identifies solvent polarity and counterion interactions as primary modulators of adduct lifetime, steric strain, and competitive decomposition pathways.

Cite This Study

François Terrier (1982) studied this question.

synapsesocial.com/papers/6a0171788d267ec217d8a92e https://doi.org/10.1021/cr00048a001

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Implication

Comprehensive review evaluates reaction rates and equilibrium states in Jackson-Meisenheimer complexes, highlighting thermodynamic principles that control nucleophilic aromatic substitution pathways.

Rate and equilibrium studies in Jackson-Meisenheimer complexes

Discussion

Member takes

Implication

Key Points

Cite This Study

Rate and equilibrium studies in Jackson-Meisenheimer complexes

Discussion

Member takes

Implication

Key Points

Cite This Study

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