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May 11, 20260 citations

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Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation.

GSGiti SahaNew York Blood Center PAPratibha AnchiNew York Blood Center RWRichard WangNew York Blood Center

Key Points

This research aims to investigate the role of ASC protein in the maturation of IL-1β and its potential as a target for treatment.
Examined the function of ASC in IL-1β maturation
Evaluated therapeutic implications for inflammasomopathies
Found that ASC acts as a critical checkpoint in the maturation of IL-1β
Indicated potential for ASC-targeted therapies in treating inflammasomopathies

Abstract

may be a therapeutically tractable node for selective modulation of IL-1β-driven inflammasomopathies.

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Cite This Study

Saha et al. (Tue,) studied this question.

synapsesocial.com/papers/6a0171ce3a9f334c28271eb0 https://doi.org/https://doi.org/10.1073/pnas.2537563123

Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation. | Synapse