Critical evaluation identifies optimal methods for quantifying procaine in various materials, suggesting enhanced stability and accuracy.
hydrolysis due to rapid analysis and minimal sample handling time. Spectroscopic assays are suitable for high-throughput pharmaceutical and environmental screening, but their applicability is limited by drug instability and cross-reactivity. Given the relative scarcity of chromatographic studies on PC despite its instability-driven analytical complexity, future work should prioritize stabilization-coupled LC-MS/MS and next-generation electrochemical platforms, together with green, miniaturized workflows and AI-assisted optimization, to enable robust, high-confidence quantification of PC in real-world matrices.
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Barzani et al. (2026) studied this question.
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