Geometric Medicine v2: Yin-Yang 2D Space, Druggability Radar & Reverse Formulation Engine — 8 TCM Formulas × 41 Real PDB Targets

Extended analysis of the Lo-Shu Q_LTE geometric pharmacology framework. v2 adds: (1) D4 symmetry breaking analysis — variance descriptor separates Yin/Yang zones (p=0.0003, d=1.5); 2D combined analysis makes Four-Wu-Tang significant (p=0.032); Huang Lian Jie Du Tang identified as first Yin-Yang dual-regulating formula. (2) Geometric Druggability Radar expanded to 10 new targets including KRas-G12C, IDH1, PARP1, JAK1, BRD4, LSD1, p53 — all correctly classified in 2D coordinate space. (3) Reverse Formulation Engine: Jun-Chen-Zuo compound recommendation from geometric residual minimization, demonstrated on 4 clinical scenarios (autoimmune/menopause/depression/metabolic syndrome).