This randomized trial analyzes the Nature Score of 79 compounds, revealing a unique thermal space for TCM formulas, suggesting new integrative prescribing strategies.
Paper 8 of the Genesis Geometric Medicine Series synthesizes three prior papers into a unified Nature Score (NS) axis spanning 79 compounds (50 TCM formulas + 29 Western drugs). Six validated equivalence pairs include Metoprolol vs Zhi Bai Rehmannia (delta NS=0.02) and Enalapril vs Polyporus Decoction (exact NS=-0.80 match). The three-layer architecture (TPSA / formula NS / lambda2) resolves the TPSA-formula paradox. Key finding: no Western drug reaches NS > +1.2 or NS < -1.5, defining the irreplaceable thermal space of TCM formulas. Integrative prescribing matrix for 7 clinical scenarios. Genesis Framework v4, n=79 compounds.
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Yao-Kai Kao (2026) studied this question.
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