Paper 8 v2 of the Genesis Geometric Medicine Series addresses five peer-review weaknesses identified in Paper 8 v1: (W1) pulse proxy: HRV literature validation added for 8 drugs, 7/8 consistent with NSₑquiv predictions; (W2) circularity: pure geometric score (TPSA+logP, no NS) independently correlates with Four-Nature (rho=0. 288, perm p=0. 079, directionally consistent) ; (W3) Western drug sample expanded n=27->n=49 adding antidepressants, antipsychotics, anticoagulants, statins, corticosteroids, bronchodilators; (W4) TCM calibration expanded n=15->n=38 (TPSA-NS rho=-0. 396, p=0. 014*, perm p=0. 013*) ; (W5) prescribing matrix renamed to hypothesis-generating atlas with explicit clinical disclaimer. Key new finding: bronchodilators (NS=+0. 60-0. 70) cluster near Ephedra Decoction (NS=+0. 75), reflecting the shared ephedrine/beta-2 mechanism. Genesis Framework v4.
Yao-Kai Kao (Wed,) studied this question.