Paper 8 v2 of the Genesis Geometric Medicine Series addresses five peer-review weaknesses identified in Paper 8 v1: (W1) pulse proxy: HRV literature validation added for 8 drugs, 7/8 consistent with NS_equiv predictions; (W2) circularity: pure geometric score (TPSA+logP, no NS) independently correlates with Four-Nature (rho=0.288, perm p=0.079, directionally consistent); (W3) Western drug sample expanded n=27->n=49 adding antidepressants, antipsychotics, anticoagulants, statins, corticosteroids, bronchodilators; (W4) TCM calibration expanded n=15->n=38 (TPSA-NS rho=-0.396, p=0.014*, perm p=0.013*); (W5) prescribing matrix renamed to hypothesis-generating atlas with explicit clinical disclaimer. Key new finding: bronchodilators (NS=+0.60-0.70) cluster near Ephedra Decoction (NS=+0.75), reflecting the shared ephedrine/beta-2 mechanism. Genesis Framework v4.
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Yao-Kai Kao (2026) studied this question.
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