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May 11, 2026BMC Neurology0 citationsOpen Access

Blood Pressure Impact on Acute Ischemic Stroke Prognosis After Thrombolysis

Relationship between blood pressure level with prognosis of acute ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis

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Authors

YLYingbin LiGHGan HuangSLShaoxue Li

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Overview

Systematic review evaluates blood pressure levels and outcomes in acute ischemic stroke patients after thrombolysis, suggesting implications for treatment.

Key Points

  • To assess the relationship between blood pressure levels and clinical outcomes after thrombolysis in acute ischemic stroke.
  • Systematic review and meta-analysis according to PRISMA guidelines.
  • Analyzed clinical studies involving adults with acute ischemic stroke treated with intravenous alteplase.
  • Pooled mean differences and odds ratios from 34 studies using fixed- or random-effects models.
  • Lower pre-treatment SBP associated with favorable functional outcomes (MD = −5.58 mmHg, 95% CI −9.04 to −2.12).
  • Post-treatment SBP also lower in favorable outcomes (MD = −4.09 mmHg, 95% CI −4.98 to −3.20).
  • Higher pre-treatment and post-treatment SBP correlated with increased rates of symptomatic intracranial hemorrhage.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a01723a3a9f334c282724c6https://doi.org/10.1186/s12883-026-04899-1
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