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May 1, 2026Osteoarthritis and CartilageOpen Access

Transient Receptor Potential Melastatin 3 ion channel expressed in sensory neurons mediates osteoarthritis pain in mice

Robson da Costa Suelen Pereira Clive Gentry Fabiana C. Dias Bianca de Lima Almeida Margot Maurer Laura I. Primicheru Lio Moreira Stefanie Mannebach Petra Weissgerber Stephan Philipp David A. Andersson Stuart Bevan

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Key Points

This research aims to determine the role of the TRPM3 ion channel in mediating osteoarthritis pain in mice.
Used genetically modified mice to study Trpm3 in osteoarthritis pain models
Conducted behavioral assessments and histological analyses
Tested TRPM3 antagonists on established pain behaviors
Global deletion of Trpm3 blocked pain behaviors in OA models (MIA MD = -7.8, PMM MD = -13.6)
Sensory neuron-specific Trpm3 deletion replicated pain reduction (PMM MD = -9.0)
Pharmacological inhibition of TRPM3 with ononetin and isosakuranetin reversed mechanical hypersensitivity in OA mice

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Implication

Shows TRPM3 ion channel mediates pain in mice with osteoarthritis, suggesting a potential treatment target.

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Cite This Study

Costa et al. (2026) studied this question.

synapsesocial.com/papers/6a01724f3a9f334c282726a4 https://doi.org/10.1016/j.joca.2026.04.015

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathyOriginal Research · 2026 · 2 citations
2Pro-inflammatory mediators sensitise Transient Receptor Potential Melastatin 3 cation channel (TRPM3) signalling in mouse sensory neurons2024 · 1 citations
3Age-dependent effects of TRPA1 deficiency on pain and osteoarthritis pathology following joint injury in miceOriginal Research · 2026
4TRPM2 is a direct pain transducerOriginal Research · 2026 · 2 citations
5TRPM2 is a direct pain transducer2025

Comparison of nociceptor properties using electrophysiology in preclinical models of osteoarthritis2024
Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes—TRPA1 and TRPM8 as Potential Drug Targets2023
TRPC3/6 Channels Mediate Mechanical Pain Hypersensitivity via Enhancement of Nociceptor Excitability and of Spinal Synaptic Transmission2024
Prevalence of Knee Radiographic Symptomatic Osteoarthritis and Ultrasound Features Across Sex and Body Mass Index Groups: The Johnston County Health StudyOsteoarthritis and Cartilage · 2026
Risk of bias in network meta-analyses of interventions for knee and hip osteoarthritis published in leading general medical and specialty journals: A methodological study using the RoB NMA toolOsteoarthritis and Cartilage · 2026

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