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May 9, 2026Journal of Cachexia Sarcopenia and MuscleOpen Access

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Sara Chiappalupi Giulia Gentili Laura Salvadori Martina Paiella Marcello Manfredi Vittoria Federica Borrini Kaamashri Mangar Ann Marie Schmidt Maurizio Muscaritoli Francesca Riuzzi Guglielmo Sorci

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Key Points

This research aims to understand how RAGE re-expression in myofibres contributes to muscle wasting in cancer.
Mice were injected with Lewis lung carcinoma cells for up to 25 days.
Histological, molecular, and proteomic analyses were conducted on muscle samples.
Muscle samples from pancreatic cancer patients were analyzed to validate mouse data.
Muscle tissues exhibited ~3-fold increase in RAGE levels (p < 0.05) in cachectic patients compared to healthy controls.
Increased enzyme activity related to glycolysis was observed, suggesting Warburg metabolism.
Ablation of RAGE in muscles led to resistance to cachexia through myofibre remodeling.

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Implication

Examines the role of RAGE in muscle wasting in cancer, suggesting potential therapeutic avenues.

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Cite This Study

Chiappalupi et al. (2026) studied this question.

synapsesocial.com/papers/6a01724f3a9f334c2827280a https://doi.org/10.1002/jcsm.70302

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