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fibroblasts enriched in liver metastatic tumors might promote generation of CD8CXCL13 cells through Notch signaling. In summary, we extensively analyzed the transcriptional differences of cell atlas between primary and liver metastatic tumors of CRC by single-cell and spatial transcriptome RNA sequencing, providing different dimensions of the development of liver metastasis in CRC.
Wang et al. (Fri,) studied this question.