Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis

Naohiko Akimoto; Melissa Zhao; Tomotaka Ugai; Rong Zhong; Mai Chan Lau; Kenji Fujiyoshi; Junko Kishikawa; Koichiro Haruki; Kota Arima; Tyler S. Twombly; Xuehong Zhang; Edward L. Giovannucci; Kana Wu; Mingyang Song; Andrew T. Chan; Yin Cao; Jeffrey A. Meyerhardt; Kimmie Ng; Marios Giannakis; Juha P. Väyrynen; Jonathan A. Nowak; Shuji Ogino

doi:10.3390/cancers13092016

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Abstract

= 0.0005). In conclusion, tumor LINE-1 hypomethylation is increasingly more common with decreasing age of colorectal cancer diagnosis, suggesting a role of global DNA hypomethylation in colorectal cancer arising in younger adults.

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Akimoto et al. (2021) studied this question.

synapsesocial.com/papers/6a01ad4ae8ec6bd19dcaf499 https://doi.org/10.3390/cancers13092016

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Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis

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Abstract

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Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis

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Abstract

Discussion

Cite This Study

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