Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Kalahe Hewage Iresha Nadeeka Madushani Herath; Jinhee Cho; Hyo Jin Kim; Duong Thi Thuy Dinh; Hyun‐Soo Kim; Ginnae Ahn; You‐Jin Jeon; Youngheun Jee

doi:10.1080/13880209.2021.1992451

January 1, 2021Pharmaceutical BiologyOpen Access

Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

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Key Points

Investigate the inhibitory effects of Sargassum horneri ethanol extract on T-helper type-2 (Th2) polarization in ovalbumin-sensitized mouse splenocytes.
Mice (N = 12 per sensitized group, alongside healthy controls) were sensitized intraperitoneally with ovalbumin (20 µg) and alum (2 mg) or vehicle on Days 0 and 14.
Splenocytes harvested from sensitized mice were challenged ex vivo with ovalbumin (100 µg/mL) with or without Sargassum horneri ethanol extract (62.5 and 125 µg/mL).
Sargassum horneri ethanol extract attenuated ovalbumin-induced Th2 differentiation and decreased the activation of transcription factors GATA3 and NLRP3.
Extract treatment completely cleared ovalbumin-induced elevations in interleukin (IL)-4 and IL-5, and suppressed IL-13 levels by 1.5-fold.

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Implication

Preclinical study demonstrates that Sargassum horneri extract suppresses Th2 polarization in sensitized splenocytes, indicating therapeutic potential for allergen-mediated immune diseases.

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Herath et al. (2021) studied this question.

synapsesocial.com/papers/6a01aefb449274ec075ca852 https://doi.org/10.1080/13880209.2021.1992451

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Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

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Implication

Discussion

Cite This Study

Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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