May 18, 1999Circulation
Thrombogenic Factors and Recurrent Coronary Events
Why the study?
Are elevated thrombogenic and lipid factors associated with an increased risk of recurrent coronary events in post-myocardial infarction patients?
Population
1045 patients enrolled 2 months after an index myocardial infarction
Comparison
Top risk quartile of hemostatic, lipid, and… vs Lower 3 risk quartiles of the respective…
Design
Cohort
Follow-up
average 26 months
Authors
Discussion
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Member takes
Implication
May refine post-MI risk stratification; leaves open whether targeting these biomarkers improves outcomes.
Structured PICO
Are elevated thrombogenic and lipid factors associated with an increased risk of recurrent coronary events in post-myocardial infarction patients?
P
Population
1045 patients enrolled 2 months after an index myocardial infarction
I
Intervention
Top risk quartile of hemostatic (e.g., D-dimer), lipid (e.g., apoB, low apoA-I), and insulin parameters
C
Comparator
Lower 3 risk quartiles of the respective parameters
O
Outcome
Coronary death or nonfatal myocardial infarctioncomposite
Elevated D-dimer and apoB, along with low apoA-I, are independent predictors of recurrent coronary events in patients recovering from myocardial infarction.
Cite This Study
Moss et al. (1999) studied this question.