Factor V Leiden (Resistance to Activated Protein C) Increases the Risk of Myocardial Infarction in Young Women
Why the study?
Does the factor V Leiden mutation increase the risk of myocardial infarction in young women?
Population
472 women aged 18 to 44 years in western Washington state, including 84 women with a first myocardial…
Comparison
Presence of Factor V Leiden mutation vs Absence of Factor V Leiden mutation
Design
Case-control
Authors
Discussion
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Member takes
Implication
May support thrombophilia evaluation in young women with MI who smoke; hypothesis-generating and should not yet change practice.
Structured PICO
Does the factor V Leiden mutation increase the risk of myocardial infarction in young women?
P
Population
472 women aged 18 to 44 years in western Washington state, including 84 women with a first myocardial infarction (MI) and 388 control women without MI.
I
Intervention
Presence of Factor V Leiden mutation (factor V Arg506Gln)
C
Comparator
Absence of Factor V Leiden mutation
O
Outcome
First myocardial infarction (MI)hard clinical
The factor V Leiden mutation significantly increases the risk of myocardial infarction in young women, with the effect appearing to be largely confined to current smokers.
Cite This Study
Rosendaal et al. (1997) studied this question.