Key result
Carriage of the Factor V Leiden mutation was significantly associated with an increased risk of myocardial infarction (OR 1.608; 95% CI 1.98-4.44; p=0.0).
Why the study?
Does the presence of Factor V Leiden mutation increase the risk of myocardial infarction?
Meta-Analysis (n=27,066)
Yes
Does the presence of Factor V Leiden mutation increase the risk of myocardial infarction?
Odds Ratio: 1.608 (95% CI 1.98–4.44)
p-value: p=0.0
Factor V Leiden mutation is associated with a significantly increased risk of myocardial infarction, suggesting a potential role for genetic counseling and prophylaxis in affected families.
FVL carriage may inform familial MI risk counseling; confirms association but leaves clinical utility open pending trials.
BACKGROUND: Myocardial infarction (MI) can be due to inherited thrombophilia caused by resistance to activated protein C resulting from factor V Leiden (FVL) mutation. OBJECTIVES: The objectives of this study were to estimate the frequency of FVL mutation among MI cases in various populations and calculate the overall risk related to it. SUBJECTS AND METHODS: Subjects comprised 7790 cases with MI and 19,276 healthy controls collected from 41 relevant studies in the search databases. The resulting frequency of FVL mutation among cases and the odds ratio were compared and integrated in a meta-analysis format. RESULTS: Although there was marked variation of the frequency of FVL mutation among different populations including MI and healthy controls, most studies reported a positive risk related to it. Compilation of analyzed studies resulted in an overall frequency of FVL mutation of 6.791% among MI cases, which was significantly higher than that among controls (1.304%, p = 0.0) with an overall odds ratio of 1.608 (95% confidence interval, 1.98-4.44). CONCLUSION: There is a definite risk related to the carriage of FVL mutation among MI cases. This should have a potential impact on the genetic counseling of family members of affected cases for proper prophylaxis.
No takes yet. Share an insight, caveat, or question.
Dowaidar et al. (2010) conducted a meta-analysis in Myocardial infarction (n=27,066). Factor V Leiden (FVL) mutation vs. Absence of FVL mutation (healthy controls) was evaluated on Myocardial infarction (OR 1.608, 95% CI 1.98-4.44, p=0.0). Carriage of the Factor V Leiden mutation was significantly associated with an increased risk of myocardial infarction (OR 1.608; 95% CI 1.98-4.44; p=0.0).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: