Key result
Factor V Leiden mutation was associated with a fourfold increase in the risk for deep vein thrombosis, with no relation observed for myocardial infarction or stroke.
Why the study?
Does the Factor V Leiden mutation increase the risk of deep vein thrombosis, myocardial infarction, or stroke in a Venezuelan population?
Case-Control (n=571)
Does the Factor V Leiden mutation increase the risk of deep vein thrombosis, myocardial infarction, or stroke in a Venezuelan population?
Answers are grounded in this paper and cite their sources.
The Factor V Leiden mutation is significantly associated with an increased risk of deep vein thrombosis, especially in women, but not with myocardial infarction or stroke in the Venezuelan population.
The most common genetic defect associated with deep vein thrombosis (DVT) is a mutation in the Factor V gene (G1691A), known as Factor V Leiden (FVL). We investigated the genotypes for FVL in 571 individuals in Venezuela: 208 patients with DVT, 175 patients with acute myocardial infarction, 54 patients with stroke, and 134 control subjects. Our results showed in the population analyzed here that the FVL was associated with a fourfold increase in the risk for DVT (odds ratio, 4.24; 95% confidence interval, 1.35-14.79); particularly, women carriers showed a 6.5-fold increase in the risk for DVT. No relation was observed between the presence of FVL and the risk for acute myocardial infarction or stroke. In conclusion, a clear association between the FVL mutation and DVT was observed in the population analyzed in Venezuela. These results are in agreement with those found in other populations with different ethnic backgrounds.
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Pestana et al. (2009) conducted a case-control in Deep vein thrombosis, acute myocardial infarction, and stroke (n=571). Factor V Leiden (FVL) mutation vs. Control subjects was evaluated on Risk for deep vein thrombosis (OR 4.24, 95% CI 1.35-14.79). Factor V Leiden mutation was associated with a fourfold increase in the risk for deep vein thrombosis, with no relation observed for myocardial infarction or stroke.
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