Population
mSlo1 large conductance Ca(2+)-activated K(+) (BK) channels
Comparison
Intracellular Ca and membrane voltage vs Absence of Ca(2+) (0 Ca(2+))
Design
Preclinical
Authors
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No immediate clinical translation; extends dual-allosteric models of BK channel gating.
Ca2+ binding and voltage sensor activation act almost independently through a dual-allosteric mechanism to enhance the opening of large conductance BK channels.
Horrigan et al. (2002) studied this question.