Population
Normally activating wild-type Shaker potassium channel and mutant channel V2
Design
Preclinical
Authors
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No immediate clinical implications for channelopathies; leaves open extension of gating models to human cardiac channels.
The Scheme 3+2' kinetic model successfully describes the activation gating process of the Shaker potassium channel, highlighting the role of L382 in conformational stability.
Schoppa et al. (1998) studied this question.
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