Population
Poliovirus genome (in vivo model)
Design
Preclinical
Authors
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Animal data on poliovirus polymerase error rate warrant no clinical extrapolation; leaves open mechanisms of viral mutagenesis for further study.
The poliovirus RNA polymerase exhibits a high error frequency in vivo (mean 4.1 x 10^-3) with no significant variation across the eight specific sites examined.
Ward et al. (1992) studied this question.
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