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May 1, 1988Journal of VirologyOpen Access

Three-dimensional structure of poliovirus serotype 1 neutralizing determinants

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Key result

In 63 poliovirus serotype 1 isolates, mutations causing altered antigenicity clustered into distinct peptide segments located within prominent structural features of the viral surface.

Population

Poliovirus (Sabin strain, serotype 1) antigenic mutants (63 isolates)

Design

Preclinical

Authors

GPGuy S. PageMassachusetts Institute of TechnologyAMAnne G. MosserUniversity of Wisconsin–MadisonJHJames M. HogleHarvard University

Discussion

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Implication

Hypothesis-generating for poliovirus antigenic variation; leaves open translation to human vaccine or escape monitoring.

Structured PICO

P
Population
Poliovirus (Sabin strain, serotype 1) antigenic mutants (63 isolates)
I
Intervention
Anti-Sabin neutralizing monoclonal antibodies (15 antibodies)
O
Outcome
Identification of amino acid replacements within the capsid protein sequence causing altered antigenicity and their location within the three-dimensional structure of the virionsurrogate

The study maps the three-dimensional structure of poliovirus serotype 1 neutralizing determinants, providing insights into the generation of neutralization-resistant variants and virus-antibody interactions.

Cite This Study

Page et al. (1988) studied Poliovirus serotype 1 (n=63). In 63 poliovirus serotype 1 isolates, mutations causing altered antigenicity clustered into distinct peptide segments located within prominent structural features of the viral surface.

synapsesocial.com/papers/6a0f9fcde3460f6d4c1cd503https://doi.org/10.1128/jvi.62.5.1781-1794.1988
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Also Consider

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  1. 1Modulation of humoral response to a 12-amino-acid site on the poliovirus virion1986 · 68 citations
  2. 2Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site1986 · 121 citations
  3. 3Antigenic Variation and Resistance to Neutralization in Poliovirus Type 11985 · 126 citations
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  5. 5Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 141986 · 303 citations