The study identifies new amino acid substitutions for neutralization resistance in poliovirus type 1 and provides evidence for linkage between subsites 3a and 3b.
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May guide poliovirus antigenic surveillance; extends epitope mapping but leaves clinical vaccine implications open pending human data.
Neutralizing monoclonal antibodies against poliovirus type 1 were obtained after conventional immunization or combined in vivo-in vitro immunization. Antibody binding sites were determined by sequence analysis of neutralization-resistant mutants. Site 3 variants had several amino acid substitutions in previously unidentified positions for neutralization resistance. Evidence for a linkage of subsites 3a and 3b is presented. Some site 3b antibodies as defined previously precipitated 14S subunits, although with reduced titers.
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Wiegers et al. (1992) studied this question.
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