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May 1, 1985Journal of General Virology

Principal and Subsidiary Antigenic Sites of VP1 Involved in the Neutralization of Poliovirus Type 3

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Population

Over 300 mutants derived from two strains of poliovirus type 3 and 59 monoclonal antibodies to poliovirus…

Design

Preclinical

Authors

PMPhilip D. MinorUniversity of EssexDED. M. A. EvansNational Institute for Biological Standards and ControlMFMichael A. J. FergusonBrigham and Women's Hospital

Discussion

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Implication

Identifies dominant poliovirus neutralizing epitope; leaves open whether VP1-based peptides elicit protective immunity in vivo.

Structured PICO

P
Population
Over 300 mutants derived from two strains of poliovirus type 3 and 59 monoclonal antibodies to poliovirus type 3
I
Intervention
Monoclonal antibodies
O
Outcome
Identification of antigenic sites involved in neutralization

Identification of the principal antigenic site of poliovirus type 3 provides a basis for developing synthetic oligopeptide vaccines.

Cite This Study

Minor et al. (1985) studied this question.

synapsesocial.com/papers/6a83189867735c513e7d61cehttps://doi.org/10.1099/0022-1317-66-5-1159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antigenic Structure of Polioviruses of Serotypes 1, 2 and 31986 · 309 citations
  2. 2Identification of an Antigenic Site in the Neutralization of Type 3 Poliovirus1984 · 4 citations
  3. 3Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis1992 · 13 citations
  4. 4Modulation of humoral response to a 12-amino-acid site on the poliovirus virion1986 · 68 citations
  5. 5Identification of a new neutralization antigenic site on poliovirus coat protein VP21984 · 42 citations