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January 1, 1984Journal of General Virology

Neutralization Epitopes on Poliovirus Type 3 Particles: an Analysis Using Monoclonal Antibodies

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Population

Poliovirus type 3 particles and 51 hybridoma cell clones secreting monoclonal antibodies

Design

Preclinical

Authors

MFMichael A. J. FergusonBrigham and Women's HospitalPMPhilip D. MinorUniversity of EssexDMD. I. MagrathAustralian National University

Discussion

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Implication

Animal data support conformational VP1 targeting for neutralization; leaves open human vaccine translation.

Structured PICO

P
Population
Poliovirus type 3 particles and 51 hybridoma cell clones secreting monoclonal antibodies
I
Intervention
Monoclonal antibodies to poliovirus type 3
O
Outcome
Virus-neutralizing properties, reactivity in antigen-blocking tests, and reactivity in immunoblot testssurrogate

Antigenic determinants involved in poliovirus type 3 neutralization are likely specified by the structural conformation of VP1 rather than by amino acid sequence alone.

Cite This Study

Ferguson et al. (1984) studied this question.

synapsesocial.com/papers/6a7065cfac440176ef291064https://doi.org/10.1099/0022-1317-65-1-197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunochemical Studies of Polioviruses: Identification of Immunoreactive Virus Capsid Polypeptides1982 · 30 citations
  2. 2Genetic and Antigenic Variation in Type 3 Polioviruses: Characterization of Strains by Monoclonal Antibodies and T1 Oligonucleotide Mapping1982 · 58 citations
  3. 3The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP11983 · 39 citations
  4. 4The Purification of Poliomyelitis Virus as Studied by Complement Fixation1957 · 108 citations
  5. 5Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies1982 · 137 citations