June 1, 1990Journal of General Virology

Differences in conformation of type 3 poliovirus antigenic sites on non-infectious empty particles and infectious virus

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Population

Type 3 poliovirus particles (C antigen and D antigen) and monoclonal antibodies

Design

Preclinical

Authors

MFMichael A. J. FergusonBrigham and Women's Hospital PMP. D. MinorNational Institute for Biological Standards and Control

Discussion

Member takes

Implication

May inform poliovirus particle-based vaccines; leaves open immunogenicity in humans.

Structured PICO

Population

Type 3 poliovirus particles (C antigen and D antigen) and monoclonal antibodies

Intervention

Characterization of reactivity with C antigen particles derived from neutralization-resistant virus strains with single amino acid substitutions

Outcome

Antibody binding to variant virusessurrogate

The study demonstrates that the amino acid sequences involved in neutralizing infectious type 3 poliovirus are also present on non-infectious particles but in different configurations.

Cite This Study

Ferguson et al. (1990) studied this question.

synapsesocial.com/papers/6a8525a676469a949f43d27f https://doi.org/10.1099/0022-1317-71-6-1271

View Full Paper

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June 1, 1990Journal of General Virology

Differences in conformation of type 3 poliovirus antigenic sites on non-infectious empty particles and infectious virus

View Full Paper

Ask AI

Bookmark

Population

Type 3 poliovirus particles (C antigen and D antigen) and monoclonal antibodies

Design

Preclinical

Authors

MFMichael A. J. FergusonBrigham and Women's Hospital PMP. D. MinorNational Institute for Biological Standards and Control

Discussion

Member takes

Implication

May inform poliovirus particle-based vaccines; leaves open immunogenicity in humans.

Structured PICO

Population

Type 3 poliovirus particles (C antigen and D antigen) and monoclonal antibodies

Intervention

Characterization of reactivity with C antigen particles derived from neutralization-resistant virus strains with single amino acid substitutions

Outcome

Antibody binding to variant virusessurrogate

The study demonstrates that the amino acid sequences involved in neutralizing infectious type 3 poliovirus are also present on non-infectious particles but in different configurations.

Cite This Study

Ferguson et al. (1990) studied this question.

synapsesocial.com/papers/6a8525a676469a949f43d27f https://doi.org/10.1099/0022-1317-71-6-1271

Also Consider

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