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December 1, 1982Journal of General Virology

Immunochemical Studies of Polioviruses: Identification of Immunoreactive Virus Capsid Polypeptides

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Population

Poliovirus type 3 antigens, antisera, and monoclonal antibodies

Design

Preclinical

Authors

RTRobin ThorpeUniversity of LondonPMPhilip D. MinorUniversity of EssexAMA. MackayUniversity of Manchester

Discussion

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Implication

May guide antigen selection for polio vaccines; leaves open translation of conformational requirements from animal models to humans.

Structured PICO

P
Population
Poliovirus type 3 antigens, antisera, and monoclonal antibodies
I
Intervention
Electrophoresis, transfer to nitrocellulose sheets, and treatment with antibody preparations (immunoblotting)
O
Outcome
Identification of immunoreactive virus capsid polypeptides recognized by antibodiessurrogate

The study demonstrates that VP1 is the immunodominant poliovirus polypeptide and suggests that virus neutralization depends on complex conformational arrangements rather than sequence determinants alone.

Cite This Study

Thorpe et al. (1982) studied this question.

synapsesocial.com/papers/6a8525a776469a949f43d286https://doi.org/10.1099/0022-1317-63-2-487
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neutralization Epitopes on Poliovirus Type 3 Particles: an Analysis Using Monoclonal Antibodies1984 · 49 citations
  2. 2Antigenic Characterization of Poliovirus Type 3 Using Monoclonal Antibodies1984 · 5 citations
  3. 3Monospecific Antisera Against Capsid Polypeptides of Poliovirus Type 1 Distinguish Antigenic Structures of Poliovirus Proteins1983 · 15 citations
  4. 4Antigenic and Structural Relatedness among Non-capsid and Capsid Polypeptides of Polioviruses belonging to Different Serotypes1981 · 13 citations
  5. 5Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies1982 · 137 citations