Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 1985Proceedings of the National Academy of SciencesOpen Access

Synthetic peptides from four separate regions of the poliovirus type 1 capsid protein VP1 induce neutralizing antibodies.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do synthetic peptides from poliovirus type 1 capsid protein VP1 induce neutralizing antibodies in rabbits and rats?

Population

Rabbits and rats

Comparison

Synthetic peptides from different regions of the… vs Peptides from other regions of VP1

Design

Preclinical

Authors

MCM ChowUniversity of the PacificRYR YabrovScripps HealthJBJames L. BittleScripps Research Institute

Discussion

Loading...

Member takes

Implication

Defines VP1 neutralizing epitopes in animal models; leaves open translation to human polio vaccines.

Structured PICO

Do synthetic peptides from poliovirus type 1 capsid protein VP1 induce neutralizing antibodies in rabbits and rats?

P
Population
Rabbits and rats
I
Intervention
Synthetic peptides from different regions of the poliovirus type 1 capsid protein VP1
C
Comparator
Peptides from other regions of VP1
O
Outcome
Induction of neutralizing antibodies against poliovirus type 1surrogate

Synthetic peptides from specific noncontiguous regions of poliovirus type 1 VP1 can induce neutralizing antibodies, defining the neutralizing determinants of the protein.

Cite This Study

Chow et al. (1985) studied this question.

synapsesocial.com/papers/6a23a336b7e293e61ca602a2https://doi.org/10.1073/pnas.82.3.910
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.1982 · 64 citations
  2. 2Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies1982 · 137 citations
  3. 3Bivalent attachment of antibody onto poliovirus leads to conformational alteration and neutralization1983 · 84 citations
  4. 4Natural variation of poliovirus neutralization epitopes1983 · 108 citations
  5. 5THE MAMMALIAN CELL-VIRUS RELATIONSHIP1959 · 168 citations