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Synthetic VP1 peptides may prime neutralizing responses in rabbits; leaves open human vaccine translation.
Two peptides representing neutralizing epitope-containing regions of the capsid protein VP1 of type 1 poliovirus were chemically synthesized. Both peptides were found capable of priming rabbits for a significant, long-lasting, anti-virus neutralizing IgG response following a single inoculation of intact virion. In addition, a third synthetic peptide, an extended version of one of the two priming peptides, was capable of eliciting a neutralizing antibody response following inoculation of the carrier-linked peptide alone.
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Wimmer et al. (1984) studied this question.
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