February 1, 1991Journal of VirologyOpen Access

Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1

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Population

Various strains of mice, including BALB/c (H-2d), H-2k, and H-2b

Design

Preclinical

Authors

CLClaude LeclercMcGill University EDEdith DériaudInserm VMV MimicInstitut Pasteur

Discussion

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Implication

May guide poliovirus vaccine research in select mouse strains; leaves open translation to human immunity and clinical use.

Structured PICO

Population

Various strains of mice, including BALB/c (H-2d), H-2k, and H-2b

Intervention

Immunization with inactivated poliovirus type 1 (PV1), PV2, PV3, or uncoupled p86-115 peptide (VP1 amino acids 86 to 115)

Outcome

Proliferative T-cell responses and identification of T-cell epitopessurrogate

Identification of a dominant, H-2 restricted T-cell epitope in the VP1 region of poliovirus type 1 that can induce specific B- and T-cell responses and neutralizing antibodies in mice.

Cite This Study

Leclerc et al. (1991) studied this question.

synapsesocial.com/papers/6a7874c8f6b553d308af2eba https://doi.org/10.1128/jvi.65.2.711-718.1991

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Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider