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August 1, 1983Proceedings of the National Academy of SciencesOpen Access

Localization of a poliovirus type 1 neutralization epitope in viral capsid polypeptide VP1.

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Population

Escherichia coli expressing poliovirus type 1 cDNA sequences coding for viral capsid polypeptide VP1

Comparison

Deletions of various lengths within the VP1… vs Undeleted VP1-beta-lactamase fusion protein

Design

Preclinical

Authors

SWSylvie van der WerfCentre National de la Recherche ScientifiqueCWCzeslaw WychowskiUniversity of North Carolina at Chapel HillPBP. BruneauInstitut Pasteur

Discussion

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Implication

Localizes a candidate C3 neutralization epitope on poliovirus VP1; hypothesis-generating and requires validation before any clinical translation.

Structured PICO

P
Population
Escherichia coli expressing poliovirus type 1 cDNA sequences coding for viral capsid polypeptide VP1
I
Intervention
Deletions of various lengths within the VP1 sequence
C
Comparator
Undeleted VP1-beta-lactamase fusion protein
O
Outcome
Reactivity with monoclonal poliovirus type 1 neutralizing antibody C3surrogate

The C3 epitope responsible for poliovirus type 1 neutralization is likely located in the region of VP1 amino acids 95-110.

Cite This Study

Werf et al. (1983) studied this question.

synapsesocial.com/papers/6a8873732c11edba2ecf2901https://doi.org/10.1073/pnas.80.16.5080
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Also Consider

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  1. 1Location and Characterization of the Antigenic Portion of the FMDV Immunizing Protein1982 · 367 citations
  2. 2Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.1982 · 64 citations
  3. 3Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus1982 · 87 citations
  4. 4Molecular cloning of the genome of poliovirus type 1.1981 · 44 citations
  5. 5Identification of the initiation site of poliovirus polyprotein synthesis1982 · 89 citations