Effects of Whole-Grain Consumption on Selected Biomarkers of Systematic Inflammation: A Systematic Review and Meta-analysis of Randomized Controlled Trials

This is the authors' abstract. We don't add key points for this paper.

= 95.4%, p < 0.001). In sensitivity analysis, the effect of whole grain intake on hs-CRP, IL-6, and TNF-α was not substantially modified by the result of a single study. Meta-regression for duration showed no significant association between the duration of study and changes in serum C-reactive protein levels (β coefficient = 0.006, standard error = 0.036; p = 0.870). Conclusions: This meta-analysis of RCTs suggested that whole grains might affect health status via improving systematic inflammation. Key teaching points: We conducted a systematic review and meta-analysis of randomized controlled trials. Whole grains consumption was associated with lower serum levels of hs-CRP and IL-6. Whole grains cannot significantly decrease serum levels of TNF-α. We could not found any source for heterogeneity. The effect of whole grains on serum inflammatory biomarkers was independent from duration.