Highlights the role of seizure-induced autonomic dysfunction in causing cardiovascular changes that may lead to sudden unexplained death in epilepsy.
Clinicians should monitor autonomic function in epilepsy patients; leaves open whether targeted interventions reduce SUDEP.
Parial and generalized seizures often affect autonomic function during seizures as well as during the interictal and postictal periods. Activation or inhibition of areas in the central autonomic network can cause cardiovascular, gastrointestinal, cutaneous, pupillary, urinary, and genital manifestations. Autonomic dysfunction during or after seizures may cause cardiac and pulmonary changes that contribute to sudden unexplained death in epilepsy.
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Orrin Devinsky (2004) studied this question.
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