Concomitant Expression of CD39, CD69, and CD103 Identifies AntitumorCD8⁺ T Cells in Breast Cancer Implications for Adoptive Cell Therapy

BACKGROUND: expanded tumor-infiltrating lymphocytes in luminal A and luminal B breast cancer (BC) subtypes. MATERIALS AND METHODS: using a standard TIL culture condition from a cohort study of 15 primary luminal A and luminal B breast cancer patients. Furthermore, we examined the expression of CD103, CD39, CD69, and CD25 biomarkers after the expansion by flow cytometry. RESULTS: subpopulation was related to BC subtype (0.0009). CONCLUSION: . The immuno-phenotyping of these markers may be targeted to improve the success of immunotherapeutic approaches, such as adoptive cellular therapy (ACT) in patients with BC.