Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

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Why the study?

Does elevated serum TMAO correlate with coronary atherosclerosis burden and long-term mortality in patients with CKD?

Structured PICO

Does elevated serum TMAO correlate with coronary atherosclerosis burden and long-term mortality in patients with CKD?

Population

Patients with CKD (n=104), a subset undergoing renal transplant (n=6), and a separate CKD cohort undergoing coronary angiography (n=220).

Intervention

Measurement of serum Trimethylamine-N-Oxide (TMAO) concentrations

Comparator

Healthy controls (for dialysis patients); pre-transplant baseline (for transplant patients)

Outcome

Correlation between serum TMAO and eGFR, coronary atherosclerosis burden, and long-term mortalitysurrogate

Serum TMAO is elevated in CKD, reduced by renal transplantation, and independently predicts coronary atherosclerosis burden and long-term mortality.

No takes yet. Share an insight, caveat, or question.

May aid prognostication in CKD; leaves open whether TMAO is modifiable or causal.

Stubbs et al. (2015) studied this question.

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