What question did this study set out to answer?

To address non-specific tracer uptake and adjacent signal spillover in [18F]-AV-1451 tau PET neuroimaging through a standardized partial volume correction workflow.

October 16, 2017Data in BriefOpen Access

Considerations and code for partial volume correcting [ 18 F]-AV-1451 tau PET data

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To address non-specific tracer uptake and adjacent signal spillover in [18F]-AV-1451 tau PET neuroimaging through a standardized partial volume correction workflow.
Identified regions of non-specific [18F]-AV-1451 binding in the skull, meninges, and choroid plexus as extra-cortical hotspots.
Developed and distributed regions-of-interest code to apply Rousset geometric transfer matrix partial volume correction across cortical and subcortical structures.
Non-specific tracer uptake in the skull and meninges introduced significant signal artifact near orbitofrontal, occipital, temporal, and parietal gray matter.
Choroid plexus off-target binding produced substantial signal spill-in to the adjacent hippocampus that required geometric transfer matrix correction to eliminate.

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Implication

Methodological study demonstrates off-target tracer binding during tau PET scans, highlighting the need for partial volume correction to eliminate false signal spillover.

Cite This Study

Baker et al. (2017) studied this question.

synapsesocial.com/papers/6a01d36f6668471b61d8aeb8 https://doi.org/10.1016/j.dib.2017.10.024

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Implication

Methodological study demonstrates off-target tracer binding during tau PET scans, highlighting the need for partial volume correction to eliminate false signal spillover.

Considerations and code for partial volume correcting [ 18 F]-AV-1451 tau PET data

Key Points

Discussion

Implication

Cite This Study

Considerations and code for partial volume correcting [ 18 F]-AV-1451 tau PET data

Key Points

Discussion

Implication

Cite This Study

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